Journal
CEREBRAL CORTEX
Volume 29, Issue 7, Pages 2947-2964Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhy162
Keywords
cognitive control network; dorsal attention network; hippocampus; MVPA; recollection
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Funding
- John D. and Catherine T. MacArthur Foundation
- Wallenberg Network Initiative on Culture, Brain, and Learning
- Marcus and Amalia Wallenberg Foundation
- seed grant from the Stanford Center for Cognitive and Neurobiological Imaging
- National Defense Science and Engineering Graduate Fellowship
- Regina Casper Stanford Graduate Fellowship
- National Science Foundation Integrative Graduate Education and Research Traineeship Grant
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Despite decades of science investigating the neural underpinnings of episodic memory retrieval, a critical question remains: how does stress influence remembering and the neural mechanisms of recollection in humans? Here, we used functional magnetic resonance imaging and multivariate pattern analyses to examine the effects of acute stress during retrieval. We report that stress reduced the probability of recollecting the details of past experience, and that this impairment was driven, in part, by a disruption of the relationship between hippocampal activation, cortical reinstatement, and memory performance. Moreover, even memories expressed with high confidence were less accurate under stress, and this stress-induced decline in accuracy was explained by reduced posterior hippocampal engagement despite similar levels of category-level cortical reinstatement. Finally, stress degraded the relationship between the engagement of frontoparietal control networks and retrieval decision uncertainty. Collectively, these findings demonstrate the widespread consequences of acute stress on the neural systems of remembering.
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