Journal
CEREBRAL CORTEX
Volume 29, Issue 5, Pages 1889-1899Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhy069
Keywords
Alzheimer's disease; FDG-PET; multimodal neuroimaging; neurodegeneration; progressive Aphasia; semantic variant primary
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Funding
- Ministere de la Sante [PHRCI 2008-A01150-55, PHRCN 2011 A01493-38, PHRCN 2012 12-006-0347]
- Agence Nationale de la Recherche (ANR) [07LVIE 006]
- Fondation Plan Alzheimer (Alzheimer Plan 2008-2012)
- Association France Alzheimer et maladies apparentees (AAP 2013)
- Fondation pour la Recherche Medicale (FRM)
- Conseil Regional de Haute Normandie
- Institut national de la Sante et de la recherche medicale (INSERM)
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Multimodal neuroimaging analyses offer additional information beyond that provided by each neuroimaging modality. Thus, direct comparisons and correlations between neuroimaging modalities allow revealing disease-specific topographic relationships. Here, we compared the topographic discrepancies between atrophy and hypometabolism in two neurodegenerative diseases characterized by distinct pathological processes, namely Alzheimer's disease (AD) versus semantic dementia (SD), to unravel their specific influence on local and global brain structure-function relationships. We found that intermodality topographic discrepancies clearly distinguished the two patient groups: AD showed marked discrepancies between both alterations, with greater hypometabolism than atrophy in large posterior associative neocortical regions, while SD showed more topographic consistency between atrophy and hypometabolism across brain regions. These findings likely reflect the multiple pathologies versus the relatively unitary pathological process underlying AD versus SD respectively. Our results evidence that multimodal neuroimaging-derived indexes can provide clinically relevant information to discriminate the two diseases, and potentially reveal distinct neuropathological processes.
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