Journal
CELLULAR SIGNALLING
Volume 41, Issue -, Pages 25-32Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2017.04.002
Keywords
GRK2; GPCR; Hypertension; Insulin resistance; Obesity; Cardiovascular diseases
Categories
Funding
- Ministerio de Economia y Compititividad (MINACO), Spain [SAF2014-55511-R]
- CIBER de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Spain (European FEDER contribution) [CB/11/00278, CB16/11/00286]
- European Foundation for the Study of Diabetes (EFSD) Novo Nordisk Partnership for Diabetes Research in Europe Grant
- Instituto de Salud Carlos III [PI13/01488]
- Fundacion Ramon Areces
- Contrato para la Formacion Postdoctoral from MINECO
- European Foundation for the Study of Diabetes [NN 2014_4] Funding Source: researchfish
Ask authors/readers for more resources
G protein-coupled receptor kinase 2 (GRK2) is emerging as a pivotal signalling hub able to integrate different transduction cascades. This ability appears to underlie its central role in different physiological and pathological conditions. Key mediators of cardiovascular function (such as catecholamines or angiotensin II) and components of the systemic milieu altered in insulin resistance conditions converge in increasing GRK2 levels in diverse cardiovascular cell types. In turn, GRK2 would simultaneously modulate several cardiovascular regulatory pathways, including GPCR and insulin signalling cascades, NO bioavailability and mitochondrial function. This fact can help explain the contribution of increased GRK2 levels to maladaptive cardiovascular function and remodeling. It also unveils GRK2 as a link between cardiovascular pathologies and co-morbidities such as obesity or type 2 diabetes. On the other hand, enhanced GRK2 expression, as observed in adipose tissues, liver or skeletal muscle during insulin resistance-related pathologies, could modify the orchestration of GPCR and insulin signalling in these crucial metabolic organs, and contribute to key features of the obese and insulin-resistant phenotype.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available