Journal
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
Volume 46, Issue 2, Pages 431-441Publisher
KARGER
DOI: 10.1159/000488610
Keywords
LncRNAs; Colorectal cancer; Tumorigenesis; Progression
Categories
Funding
- National Natural Science Foundation of China [81560385]
- Medical Scientific and Technological Research Project of Henan Province [201702027]
- Youth Innovation Fund Project of The First Affiliated Hospital of Zhengzhou University [YNQN2017035]
- China Postdoctoral Science Foundation [2017M610462]
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Colorectal cancer (CRC) is one of the most common malignancies in the world. Easier recurrence and metastasis is the main cause of mortality in CRC patients, and the markers applied for diagnosis and treatment of CRC is still urgently needed to early diagnose and evaluate therapeutic effect. Long noncoding RNA (lncRNA) is a class of noncoding RNA that the length is more than 200 nucleotides. With the development of sequencing technique about transcriptome, increasing lncRNAs are focused on their function and mechanism related to the nosogenesis and pathology of CRC. Recent studies report that lncRNAs acted as crucial role in CRC and could be as biomarker for CRC diagnosis and treatment. In this review, we display the regulation of lncRNA by interacting with DNA, RNA and protein and highlight the double role of lncRNAs as oncogene or anti-tumor gene involved in Wnt signaling pathway, p53 signaling pathway or others to be an regulator in CRC development. Lastly, we discuss some new finding of lncRNAs, especially lncRNA in exosome, which could be as potential markers for diagnosis and treatment of CRC in future. (C) 2018 The Author(s) Published by S. Karger AG, Basel
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