Journal
CELLULAR MICROBIOLOGY
Volume 20, Issue 8, Pages -Publisher
WILEY
DOI: 10.1111/cmi.12884
Keywords
flavivirus replication; lipids; membrane curvature; replication complex
Categories
Funding
- National Health and Medical Research Council [1081756]
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Flavivirus replication is intimately involved with remodelled membrane organelles that are compartmentalised for different functions during their life cycle. Recent advances in lipid analyses and gene depletion have identified a number of host components that enable efficient virus replication in infected cells. Here, we describe the current understanding on the role and contribution of host lipids and membrane bending proteins to flavivirus replication, with a particular focus on the components that bend and shape the membrane bilayer to induce the flavivirus-induced organelles characteristic of infection.
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