Journal
CELLULAR IMMUNOLOGY
Volume 333, Issue -, Pages 46-57Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2018.03.007
Keywords
Glycosylation in cancer; Biomarkers; Receptor tyrosine kinase; Cadherins; Integrins; Proteoglycans; Selectins; Galectins; Siglecs; Metastasis
Categories
Funding
- FEDER funds through the Operational Programme for Competitiveness Factors-COMPETE [POCI-01-0145-FEDER-016585, POCI-01-0145-FEDER-007274]
- National Funds through the Foundation for Science and Technology (FCT) [PTDC/BBB-EBI/0567/2014, PTDC/DTP-PIC/0560/2014, UID/BIM/04293/2013]
- Norte Portugal Regional Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) [NORTE-01-0145-FEDER-000029]
- FCT, POPH (Programa Operacional Potencial Humano) [SFRH/BPD/96510/2013]
- European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant [748880]
- Marie Curie Actions (MSCA) [748880] Funding Source: Marie Curie Actions (MSCA)
- Fundação para a Ciência e a Tecnologia [UID/BIM/04293/2013, PTDC/DTP-PIC/0560/2014] Funding Source: FCT
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Tumour metastasis is the main cause of cancer related deaths. Metastasis is an intricate multi-step process that requires the acquisition of several cancer cell features, including the modulation of tumour cell migration, adhesion, invasion, and immune evasion. Changes in the cellular glycosylation are associated with malignant transformation of cancer cells, tumour progression and ultimately, metastasis formation. Glycans have major impact on cellular signalling and on the regulation of tumour cell-cell adhesion and cell-matrix interaction. Glycans drive the interplay between the cancer cells and the tumour microenvironment. In this review, we summarize the roles of glycan alterations in tumour progression, such as acquisition of oncogenic features due to modulation of receptor tyrosine kinases, proteoglycans, cadherins and integrins. We also highlight the importance of key glycan binding proteins such as selectins, siglecs and galectins, which are pivotal in the modulation of immune response. An overview on glycans as cancer biomarkers is also presented.
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