Journal
CELLULAR IMMUNOLOGY
Volume 330, Issue -, Pages 168-174Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2018.01.010
Keywords
Lymph node; Macrophage
Categories
Funding
- European Research Council (ERC) under European Union [647257]
- European Research Council (ERC) [647257] Funding Source: European Research Council (ERC)
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Lymph nodes (LN) are secondary lymphoid organs dispersed throughout the body that filter lymph and assist the immune system in mounting immune responses. These functions are supported by a complex stromal microarchitecture composed of mesenchymal and vascular elements. Different subsets of macrophages (MF) reside in the LN and are endowed with immune and trophic functions. Here we review these different subsets with particular emphasis on the recently described T cell zone MF. We also address the potential crosstalk between LN stromal cells and MF, proposing that the former constitute niches for the latter by supplying factors required for their specification, survival and turnover. In turn, MF could inform their stromal partners about the immune status of the LN and orchestrate the remodelling of its microanatomy during immune responses.
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