Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 75, Issue 13, Pages 2303-2319Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-018-2804-1
Keywords
Hippo pathway; YAP/TAZ; TEAD; Cancer; Therapeutic target
Categories
Funding
- Ministry of Health and Welfare, Republic of Korea [HI17C1560] Funding Source: Medline
- National Research Foundation of Korea [2017R1A4A1015328, 2018R1C1B6004301] Funding Source: Medline
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The Hippo tumor suppressor pathway, which is well conserved from Drosophila to humans, has emerged as the master regulator of organ size, as well as major cellular properties, such as cell proliferation, survival, stemness, and tissue homeostasis. The biological significance and deregulation of the Hippo pathway in tumorigenesis have received a surge of interest in the past decade. In the current review, we present the major discoveries that made substantial contributions to our understanding of the Hippo pathway and discuss how Hippo pathway components contribute to cellular signaling, physiology, and their potential implications in anticancer therapeutics.
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