Related references
Note: Only part of the references are listed.Structural mechanisms of HECT-type ubiquitin ligases
Sonja Lorenz
BIOLOGICAL CHEMISTRY (2018)
The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/-catenin pathway by inhibiting the proteasome
Jason J. Yi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
A Tunable Brake for HECT Ubiquitin Ligases
Zan Chen et al.
MOLECULAR CELL (2017)
The PIAS3-Smurf2 sumoylation pathway suppresses breast cancer organoid invasiveness
Amrita Singh Chandhoke et al.
ONCOTARGET (2017)
A conformational switch regulates the ubiquitin ligase HUWE1
Bodo Sander et al.
ELIFE (2017)
The Nedd8 Non-covalent Binding Region in the Smurf HECT Domain is Critical to its Ubiquitn Ligase Function
Shan He et al.
SCIENTIFIC REPORTS (2017)
Allosteric auto-inhibition and activation of the Nedd4 family E3 ligase Itch
Kang Zhu et al.
EMBO REPORTS (2017)
Regulation of PTEN degradation and NEDD4-1 E3 ligase activity by Numb
Chen Shao et al.
CELL CYCLE (2017)
Ubiquitylation-dependent oligomerization regulates activity of Nedd4 ligases
Ilan Attali et al.
EMBO JOURNAL (2017)
The ubiquitin ligase Smurf2 suppresses TGFβ-induced epithelial-mesenchymal transition in a sumoylation-regulated manner
A. S. Chandhoke et al.
CELL DEATH AND DIFFERENTIATION (2016)
Syk-mediated tyrosine phosphorylation of mule promotes TNF-induced JNK activation and cell death
C. K. Lee et al.
ONCOGENE (2016)
Nedd8 targets ubiquitin ligase Smurf2 for neddylation and promote its degradation
Jingyi Shu et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)
E2 enzymes: more than just middle men
Mikaela D. Stewart et al.
CELL RESEARCH (2016)
Functional and pathological relevance of HERC family proteins: a decade later
Susana Sanchez-Tena et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2016)
Itch promotes the neddylation of JunB and regulates JunB-dependent transcription
Haiwen Li et al.
CELLULAR SIGNALLING (2016)
Trip12 is an E3 ubiquitin ligase for USP7/HAUSP involved in the DNA damage response
Xiaoliang Liu et al.
FEBS LETTERS (2016)
ITCH E3 Ubiquitin Ligase Interacts with Ebola Virus VP40 To Regulate Budding
Ziying Han et al.
JOURNAL OF VIROLOGY (2016)
System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes
Wei Zhang et al.
MOLECULAR CELL (2016)
Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53
Denise Martinez-Zapien et al.
NATURE (2016)
Synthesis of Isomeric Phosphoubiquitin Chains Reveals that Phosphorylation Controls Deubiquitinase Activity and Specificity
Nicolas Huguenin-Dezot et al.
CELL REPORTS (2016)
Covalent ISG15 conjugation positively regulates the ubiquitin E3 ligase activity of parkin
Eunju Im et al.
OPEN BIOLOGY (2016)
Analysis of Multiple HPV E6 PDZ Interactions Defines Type-Specific PDZ Fingerprints That Predict Oncogenic Potential
Miranda Thomas et al.
PLOS PATHOGENS (2016)
An Autism-Linked Mutation Disables Phosphorylation Control of UBE3A
Jason J. Yi et al.
CELL (2015)
Expanding the ubiquitin code through post-translational modification
Lina Herhaus et al.
EMBO REPORTS (2015)
Ubiquitin-Specific Protease 7 Accelerates p14ARF Degradation by Deubiquitinating Thyroid Hormone Receptor-Interacting Protein 12 and Promotes Hepatocellular Carcinoma Progression
Jia-Bin Cai et al.
HEPATOLOGY (2015)
Itch WW Domains Inhibit Its E3 Ubiquitin Ligase Activity by Blocking E2-E3 Ligase Trans-thiolation
Christopher Riling et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
A Small Molecule That Switches a Ubiquitin Ligase From a Processive to a Distributive Enzymatic Mechanism
Stefan G. Kathman et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)
Protein neddylation: beyond cullin-RING ligases
Radoslav I. Enchev et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2015)
Role of ubiquitin and the HPV E6 oncoprotein in E6AP-mediated ubiquitination
Franziska Mortensen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy
Ketaki Ganti et al.
VIRUSES-BASEL (2015)
Identification and Characterization of Small Molecule Human Papillomavirus E6 Inhibitors
Kimberly A. Malecka et al.
ACS CHEMICAL BIOLOGY (2014)
Neutron-Encoded Mass Signatures for Quantitative Top-Down Proteomics
Timothy W. Rhoads et al.
ANALYTICAL CHEMISTRY (2014)
RING-type E3 ligases: Master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination
Meredith B. Metzger et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2014)
Mammalian HECT ubiquitin-protein ligases: Biological and pathophysiological aspects
Martin Scheffner et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2014)
Structure of a RING E3 Trapped in Action Reveals Ligation Mechanism for the Ubiquitin-like Protein NEDD8
Daniel C. Scott et al.
CELL (2014)
Development of inhibitors in the ubiquitination cascade
Wei Zhang et al.
FEBS LETTERS (2014)
The Active Form of E6-associated protein (E6AP)/UBE3A Ubiquitin Ligase Is an Oligomer
Virginia P. Ronchi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Small-Molecule Probes Targeting the Viral PPxY-Host Nedd4 Interface Block Egress of a Broad Range of RNA Viruses
Ziying Han et al.
JOURNAL OF VIROLOGY (2014)
Autoregulation of the 26S proteasome by in situ ubiquitination
Andrew D. Jacobson et al.
MOLECULAR BIOLOGY OF THE CELL (2014)
Ubiquitin is phosphorylated by PINK1 to activate parkin
Fumika Koyano et al.
NATURE (2014)
The contribution of de novo coding mutations to autism spectrum disorder
Ivan Iossifov et al.
NATURE (2014)
Tyrosine phosphorylation of NEDD4 activates its ubiquitin ligase activity
Avinash Persaud et al.
SCIENCE SIGNALING (2014)
Structural Basis of the Activation and Degradation Mechanisms of the E3 Ubiquitin Ligase Nedd4L
Albert Escobedo et al.
STRUCTURE (2014)
The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis
Ping Xie et al.
NATURE COMMUNICATIONS (2014)
c-Abl Phosphorylates E6AP and Regulates Its E3 Ubiquitin Ligase Activity
Ai-Leen Chan et al.
BIOCHEMISTRY (2013)
Building and remodelling Cullin-RING E3 ubiquitin ligases - 'Ubiquitylation: mechanism and functions' review series
John R. Lydeard et al.
EMBO REPORTS (2013)
Structural Basis for Hijacking of Cellular LxxLL Motifs by Papillomavirus E6 Oncoproteins
Katia Zanier et al.
SCIENCE (2013)
Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3
Hari B. Kamadurai et al.
ELIFE (2013)
The Ubiquitin Code
David Komander et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 81 (2012)
ESpritz: accurate and fast prediction of protein disorder
Ian Walsh et al.
BIOINFORMATICS (2012)
Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia
Jason Howitt et al.
JOURNAL OF CELL BIOLOGY (2012)
Conserved Region 3 of Human Papillomavirus 16 E7 Contributes to Deregulation of the Retinoblastoma Tumor Suppressor
Biljana Todorovic et al.
JOURNAL OF VIROLOGY (2012)
HERC6 Is the Main E3 Ligase for Global ISG15 Conjugation in Mouse Cells
Diede Oudshoorn et al.
PLOS ONE (2012)
Crystal structures of two bacterial HECT-like E3 ligases in complex with a human E2 reveal atomic details of pathogen-host interactions
David Yin-wei Lin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Structural Basis for the Versatile Interactions of Smad7 with Regulator WW Domains in TGF-β Pathways
Eric Aragon et al.
STRUCTURE (2012)
Ubiquitination of E3 ligases: self-regulation of the ubiquitin system via proteolytic and non-proteolytic mechanisms
P. de Bie et al.
CELL DEATH AND DIFFERENTIATION (2011)
Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation
Elena Maspero et al.
EMBO REPORTS (2011)
Structure and function of a HECT domain ubiquitin-binding site
Hyung Cheol Kim et al.
EMBO REPORTS (2011)
Binding of RhoA by the C2 domain of E3 ligase Smurf1 is essential for Smurf1-regulated RhoA ubiquitination and cell protrusive activity
Maoyuan Tian et al.
FEBS LETTERS (2011)
Physical and Functional Interaction of the HECT Ubiquitin-protein Ligases E6AP and HERC2
Simone Kuehnle et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Zn-binding AZUL domain of human ubiquitin protein ligase Ube3A
Alexander Lemak et al.
JOURNAL OF BIOMOLECULAR NMR (2011)
Interferon-Stimulated Gene 15 and the Protein ISGylation System
Dongxian Zhang et al.
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2011)
Regulation of the Human Papillomavirus Type 18 E6/E6AP Ubiquitin Ligase Complex by the HECT Domain-Containing Protein EDD
Vjekoslav Tomaic et al.
JOURNAL OF VIROLOGY (2011)
Cdh1 Is a HECT of an Activator
Luying Jia et al.
MOLECULAR CELL (2011)
Cdh1 Regulates Osteoblast Function through an APC/C-Independent Modulation of Smurf1
Lixin Wan et al.
MOLECULAR CELL (2011)
WWP2 is an E3 ubiquitin ligase for PTEN
Subbareddy Maddika et al.
NATURE CELL BIOLOGY (2011)
The Ubiquitin Binding Region of the Smurf HECT Domain Facilitates Polyubiquitylation and Binding of Ubiquitylated Substrates
Abiodun A. Ogunjimi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses
Delin Chen et al.
NATURE (2010)
The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases
Cheol-Sang Hwang et al.
NATURE CELL BIOLOGY (2010)
Regulation of the RSP5 Ubiquitin Ligase by an Intrinsic Ubiquitin-binding Site
Michael E. French et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Polyubiquitination by HECT E3s and the Determinants of Chain Type Specificity
Hyung Cheol Kim et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
Insights into Ubiauitin Transfer Cascades from a Structure of a UbcH5B∼Ubiauitin-HECTNEDD4L Complex
Hari B. Kamadurai et al.
MOLECULAR CELL (2009)
Itch self-polyubiquitylation occurs through lysine-63 linkages
Flavia Scialpi et al.
BIOCHEMICAL PHARMACOLOGY (2008)
The ubiquitin system, disease, and drug discovery
Matthew D Petroski
BMC BIOCHEMISTRY (2008)
Tenets of PTEN tumor suppression
Leonardo Salmena et al.
CELL (2008)
ISG15 inhibits Nedd4 ubiquitin E3 activity and enhances the innate antiviral response
Oxana A. Malakhova et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
ISG15 inhibit Ebola VP40VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity
Atsushi Okumura et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Human papillomavirus type 16 E7 oncoprotein associates with the cullin 2 ubiquitin ligase complex, which contributes to degradation of the retinoblastoma tumor suppressor
KyungWon Huh et al.
JOURNAL OF VIROLOGY (2007)
Autoinhibition of the HECT-Type ubiquitin ligase smurf2 through its c2 domain
Silke Wiesner et al.
CELL (2007)
Smad4 is required for maintaining normal murine postnatal bone homeostasis
Xiaohong Tan et al.
JOURNAL OF CELL SCIENCE (2007)
Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages
Hyoung Tae Kim et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Degradation of tyrosine phosphatase PTPN3 (PTPH1) by association with oncogenic human papillomavirus E6 proteins
Ming Jing et al.
JOURNAL OF VIROLOGY (2007)
E6A-P-dependent degradation of DLG4/PSD95 by high-risk human papillomavirus type 18 E6 protein
Keisuke Handa et al.
JOURNAL OF VIROLOGY (2007)
Ubiquitination regulates PTEN nuclear import and tumor suppression
Lloyd C. Trotman et al.
CELL (2007)
The role of the ubiquitin ligase E6-AP in human papillomavirus E6-mediated degradation of PDZ domain-containing proteins
Petric Kuballa et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation
Paula M. Oliver et al.
IMMUNITY (2006)
The inflammation-associated Salmonella SopA is a HECT-like E3 ubiquitin ligase
Ying Zhang et al.
MOLECULAR MICROBIOLOGY (2006)
Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains
Patricia Chastagner et al.
EMBO REPORTS (2006)
Ubiquitin-dependent regulation of TGFβ signaling in cancer
Luisa Izzi et al.
NEOPLASIA (2006)
HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets
Joyce Jing Yi Wong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Drug discovery in the ubiquitin-proteasome system
Grzegorz Nalepa et al.
NATURE REVIEWS DRUG DISCOVERY (2006)
Targeting retinoblastoma protein for degradation by proteasomes
Haoqiang Ying et al.
CELL CYCLE (2006)
Herc5, an interferon-induced HECT E3 enzyme, is required for conjugation of ISG15 in human cells
A Dastur et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change
E Gallagher et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Different HECT domain ubiquitin ligases employ distinct mechanisms of polyubiquitin chain synthesis
M Wang et al.
EMBO JOURNAL (2005)
E2 conjugating enzymes must disengage from their E1 enzymes before E3-dependent ubiquitin and ubiquitin-like transfer
ZM Eletr et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2005)
Two distinct activities contribute to human papillomavirus 16 E6's oncogenic potential
SJS Simonson et al.
CANCER RESEARCH (2005)
Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain
AA Ogunjimi et al.
MOLECULAR CELL (2005)
WW domains provide a platform for the assembly of multiprotein networks
RJ Ingham et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
The Rsp5 ubiquitin ligase is coupled to and antagonized by the Ubp2 deubiquitinating enzyme
Y Kee et al.
EMBO JOURNAL (2005)
ARF-BP1/mule is a critical mediator of the ARF tumor suppressor
DL Chen et al.
CELL (2005)
The global transcriptional effects of the human papillomavirus E6 protein in cervical carcinoma cell lines are mediated by the E6AP ubiquitin ligase
ML Kelley et al.
JOURNAL OF VIROLOGY (2005)
The C2 domain of the Rsp5 ubiquitin ligase binds membrane phosphoinositides and directs ubiquitination of endosomal cargo
R Dunn et al.
JOURNAL OF CELL BIOLOGY (2004)
The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture
RJ Ingham et al.
ONCOGENE (2004)
Degradation of hDIg and MAGIs by human papillomavirus E6 is E6-AP-independent
HS Grm et al.
JOURNAL OF GENERAL VIROLOGY (2004)
Identification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6-AP complex
L Gewin et al.
GENES & DEVELOPMENT (2004)
Mechanisms of human papillomavirus-induced oncogenesis
K Münger et al.
JOURNAL OF VIROLOGY (2004)
Role of the PDZ domain-binding motif of the oncoprotein E6 in the pathogenesis of human papillomavirus type 31
CH Lee et al.
JOURNAL OF VIROLOGY (2004)
Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase itch
M Gao et al.
SCIENCE (2004)
Activity of the human papillomavirus E6 PDZ-binding motif correlates with an enhanced morphological transformation of immortalized human keratinocytes
RA Watson et al.
JOURNAL OF CELL SCIENCE (2003)
Nedd4 regulates egress of Ebola virus-like particles from host cells
J Yasuda et al.
JOURNAL OF VIROLOGY (2003)
The PDZ ligand domain of the human papillomavirus type 16 E6 protein is required for E6's induction of epithelial hyperplasia in vivo
ML Nguyen et al.
JOURNAL OF VIROLOGY (2003)
Ebola virus matrix protein VP40 interaction with human cellular factors Tsg101 and Nedd4
J Timmins et al.
JOURNAL OF MOLECULAR BIOLOGY (2003)
Conformational flexibility underlies ubiquitin ligation mediated by the WWP1HECT domain E3 ligase
MA Verdecia et al.
MOLECULAR CELL (2003)
Rho GTPases and the regulation of endothelial permeability
B Wojciak-Stothard et al.
VASCULAR PHARMACOLOGY (2002)
Target-assisted iterative screening reveals novel interactors for PSD95, Nedd4, Src, Abl and Crk proteins
A Kurakin et al.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2002)
DTASelect and contrast: Tools for assembling and comparing protein identifications from shotgun proteomics
DL Tabb et al.
JOURNAL OF PROTEOME RESEARCH (2002)
Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na+ channel cell surface expression
C Debonneville et al.
EMBO JOURNAL (2001)
Both Rb and E7 are regulated by the ubiquitin proteasome pathway in HPV-containing cervical tumor cells
J Wang et al.
ONCOGENE (2001)
Chromatin docking and exchange activity enhancement of RCC1 by histones H2A and H2B
ME Nemergut et al.
SCIENCE (2001)
Human papillomavirus type 16 E6-induced degradation of E6TP1 correlates with its ability to immortalize human mammary epithelial cells
QS Gao et al.
JOURNAL OF VIROLOGY (2001)
Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions
T Tanoue et al.
EMBO JOURNAL (2001)
A PPxY motif within the VP40 protein of Ebola virus interacts physically and functionally with a ubiquitin ligase: Implications for filovirus budding
RN Harty et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Role of Bak in UV-induced apoptosis in skin cancer and abrogation by HPV E6 proteins
S Jackson et al.
GENES & DEVELOPMENT (2000)
Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase
S Nakagawa et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
Cell cycle-regulated modification of the ribosome by a variant multiubiquitin chain
J Spence et al.
CELL (2000)
Chromatin-independent nuclear envelope assembly induced by Ran GTPase in Xenopus egg extracts
CM Zhang et al.
SCIENCE (2000)