Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 75, Issue 12, Pages 2125-2135Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-018-2788-x
Keywords
Suppressive; Gammadelta; T Lymphocytes; FoxP3; Adenosine; Checkpoint; TGF-beta; IL-10
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Funding
- Else-Kroner-Fresenius Foundation [2013_A276]
- Excellence Cluster - DFG [ExC 306]
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gamma delta T cells share characteristics of innate and adaptive immune cells and are involved in a broad spectrum of pro-inflammatory functions. Nonetheless, there is accumulating evidence that gamma delta T cells also exhibit regulatory functions. In this review, we describe the different phenotypes of regulatory gamma delta T cells in correlation with the identified mechanisms of suppression.
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