Journal
CELL STEM CELL
Volume 22, Issue 6, Pages 810-823Publisher
CELL PRESS
DOI: 10.1016/j.stem.2018.05.016
Keywords
-
Categories
Funding
- NIH [U01EB025136, DK105831]
- JDRF Encapsulation Consortium [3-SRA-2015-37-Q-R]
Ask authors/readers for more resources
Restoration of insulin independence and normoglycemia has been the overarching goal in diabetes research and therapy. While whole-organ and islet transplantation have become gold-standard procedures in achieving glucose control in diabetic patients, the profound lack of suitable donor tissues severely hampers the broad application of these therapies. Here, we describe current efforts aimed at generating a sustainable source of functional human stem cell-derived insulin-producing islet cells for cell transplantation and present state-of-the-art efforts to protect such cells via immune modulation and encapsulation strategies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available