Journal
CELL STEM CELL
Volume 22, Issue 6, Pages 824-833Publisher
CELL PRESS
DOI: 10.1016/j.stem.2018.05.004
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Funding
- NIH/NIDDK [R01DK109508]
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Mesenchymal stromal cells (MSCs) have been the subject of clinical trials for more than a generation, and the outcomes of advanced clinical trials have fallen short of expectations raised by encouraging pre-clinical animal data in a wide array of disease models. In this Perspective, important biological and pharmacological disparities in pre-clinical research and human translational studies are highlighted, and analyses of clinical trial failures and recent successes provide a rational pathway to MSC regulatory approval and deployment for disorders with unmet medical needs.
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