Journal
CELL STEM CELL
Volume 22, Issue 5, Pages 639-651Publisher
CELL PRESS
DOI: 10.1016/j.stem.2018.04.015
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Funding
- ERC [341096]
- MINECO [SAF2016-75613-R]
- Generalitat de Catalunya [PERIS- SLT002/16/00299, 2017SGR135]
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Evidence of the diversity and multi-layered organization of the hematopoietic system is leading to new insights that may inform ex vivo production of blood cells. Interestingly, not all long-lived hematopoietic cells derive from hematopoietic stem cells (HSCs). Here we review the current knowledge on HSC-dependent cell lineages and HSC-independent tissue-resident hematopoietic cells and how they arise during embryonic development. Classical embryological and genetic experiments, cell fate tracing data, single-cell imaging, and transcriptomics studies provide information on the molecular/cell trajectories that form the complete hematopoietic system. We also discuss the current developmentally informed efforts toward generating engraftable and multilineage blood cells.
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