Journal
CELL PROLIFERATION
Volume 51, Issue 4, Pages -Publisher
WILEY
DOI: 10.1111/cpr.12449
Keywords
BANCR; long noncoding RNAs (lncRNAs); tumour accelerator; tumour suppressor
Categories
Funding
- First Hospital of Jilin University Grant [JDYY72016055]
Ask authors/readers for more resources
Long non-coding RNAs (lncRNAs) participate in the complex network of cancer and play an important role in tumourigenesis and progression. BRAF activated non-coding RNA (BANCR), a 4-exon transcript of 693-bp, was first discovered as an oncogeniclong non-coding RNA in BRAF(V600E) melanomas cells in 2012 and was related to melanoma cell migration. Besides melanoma, increasing evidence has explored the potential role of BANCR in the development and progression of multiple other human malignancies, such as retinoblastoma, lung cancer, gastric cancer etc. since its discovery. The expression pattern of BANCR varies in different types of cancers, either as a tumour suppressor or as an accelerator. Functional BANCR may serve as a promising biomarker for cancer diagnosis as well as prognosis evaluation. BANCR-targeted intervention may also become a valuable novel therapeutic tool against human malignancies. This review summarized the advanced research progresses concerning the expression and role of BANCR in different human malignancies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available