Journal
CELL METABOLISM
Volume 28, Issue 4, Pages 656-+Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2018.06.019
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Funding
- NIDDK Mouse Metabolic Phenotyping Centers (MMPC) under the MICROMouse Program [DK076169, DK115255]
- Harvard Digestive Disease Center [DK034854]
- NIH [OD020100]
- ARRA [DK048873-14S2, DK048873, DK056626, DK103046, DK107717]
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We report a web-based tool for analysis of experiments using indirect calorimetry to measure physiological energy balance. CaIR simplifies the process to import raw data files, generate plots, and determine the most appropriate statistical tests for interpretation. Analysis using the generalized linear model (which includes ANOVA and ANCOVA) allows for flexibility in interpreting diverse experimental designs, including those of obesity and thermogenesis. Users also may produce standardized output files for an experiment that can be shared and subsequently re-evaluated using CaIR. This framework will provide the transparency necessary to enhance consistency, rigor, and reproducibility. The CaIR analysis software will greatly increase the speed and efficiency with which metabolic experiments can be organized, analyzed per accepted norms, and reproduced and will likely become a standard tool for the field.
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