Journal
CELL METABOLISM
Volume 28, Issue 1, Pages 45-+Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2018.05.004
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Funding
- Swedish Research Council
- Novo Nordisk Foundation including the Tripartite Immuno-metabolism Consortium (TrIC) [NNF15CC0018486]
- MSAM consortium [NNF15SA0018346]
- CIMED
- Swedish Diabetes Foundation
- EFSD-Lilly
- Stockholm County Council
- Diabetes Research Program at Karolinska Institutet
- CLARINS [92200]
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Adipocyte mobilization of fatty acids (lipolysis) is instrumental for energy expenditure. Lipolysis displays both spontaneous (basal) and hormone-stimulated activity. It is unknown if lipolysis is important for future body weight gain and associated disturbed glucose metabolism, and this was presently investigated in subcutaneous adipocytes from two female cohorts before and after >= 10-year follow-up. High basal and low stimulated lipolysis at baseline predicted future weight gain (odds ratios >= 4.6) as well as development of insulin resistance and impaired fasting glucose/type 2 diabetes (odds ratios >= 3.2). At baseline, weight gainers displayed lower adipose expression of several established lipolysis-regulating genes. Thus, inefficient lipolysis (high basal/low stimulated) involving altered gene expression is linked to future weight gain and impaired glucose metabolism and may constitute a treatment target. Finally, low stimulated lipolysis could be accurately estimated in vivo by simple clinical/biochemical measures and may be used to identify risk individuals for intensified preventive measures.
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