Journal
CELL METABOLISM
Volume 27, Issue 1, Pages 10-21Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2017.09.015
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Funding
- Danish Cancer Society [R98-A6417]
- TrygFonden
- Lundbeck Foundation [R238-2016-2821]
- Danish National Research Foundation [DNRF55]
- Danish Council for Strategic Research [09-067009, 09-075724]
- Lundbeck Foundation [R238-2016-2821] Funding Source: researchfish
- The Danish Cancer Society [R119-A7313, R98-A6417] Funding Source: researchfish
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The benefits of exercise training for cancer patients are becoming increasingly evident. Physical exercise has been shown to reduce cancer incidence and inhibit tumor growth. Here we provide the status of the current molecular understanding of the effect of exercise on cancer. We propose that exercise has a role in controlling cancer progression through a direct effect on tumor-intrinsic factors, interplay with whole-body exercise effects, alleviation of cancer-related adverse events, and improvement of anti-cancer treatment efficacy. These findings have wide-ranging societal implications, as this understanding may lead to changes in cancer treatment strategies.
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