Journal
CELL METABOLISM
Volume 28, Issue 2, Pages 282-+Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2018.05.022
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Funding
- U.S. NIH [R01DK55758, R01DK099110, P01DK088761, P01AG051459, K01DK107788, R03HD095414, R01DK104789]
- Cancer Prevention Research Institute of Texas [RP140412]
- Novo Nordisk Research Foundation
- City of Hope Shared Resources Pilot Program award
- AHA postdoctoral fellowship [16POST26420136]
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [R03HD095414] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK055758, P01DK088761, R01DK104789, R01DK099110, K01DK107788] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [P01AG051459] Funding Source: NIH RePORTER
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Adipose tissue in the mammary gland undergoes dramatic remodeling during reproduction. Adipocytes are replaced by mammary alveolar structures during pregnancy and lactation, then reappear upon weaning. The fate of the original adipocytes during lactation and the developmental origin of the re-appearing adipocyte post involution are unclear. Here, we reveal that adipocytes in the mammary gland de-differentiate into Pdgfr alpha(+) preadipocyte- and fibroblast-like cells during pregnancy and remain de-differentiated during lactation. Upon weaning, de-differentiated fibroblasts proliferate and re-differentiate into adipocytes. This cycle occurs over multiple pregnancies. These observations reveal the potential of terminally differentiated adipocytes to undergo repeated cycles of de-differentiation and re-differentiation in a physiological setting.
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