Journal
CELL HOST & MICROBE
Volume 23, Issue 1, Pages 27-+Publisher
CELL PRESS
DOI: 10.1016/j.chom.2017.11.004
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Funding
- Swedish Research Council
- NovoNordisk foundation
- Swedish Heart-Lung Foundation
- Goran Gustafsson's Foundation
- IngaBritt och Arne Lundbergs Foundation
- Knut and Alice Wallenberg Foundation
- National Institute of Allergy and Infectious Diseases [U01AI095473]
- Hasselblad foundation
- FP7 sponsored program METACARDIS
- Region Vastra Gotaland
- Sahlgrenska University Hospital
- European Research Council [615362 - METABASE]
- European Research Council Advanced Grant [694181 - MUC2GO]
- Marie Curie Intra European Fellowship [622909 - MUCUS AND METABOLISM]
- Human Frontier Science Program Long-Term Fellowship
- NNF Center for Basic Metabolic Research [Bäckhed Group] Funding Source: researchfish
- Novo Nordisk Fonden [NNF13OC0008163] Funding Source: researchfish
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Diet strongly affects gut microbiota composition, and gut bacteria can influence the colonic mucus layer, a physical barrier that separates trillions of gut bacteria from the host. However, the interplay between a Western style diet (WSD), gut microbiota composition, and the intestinal mucus layer is less clear. Here we show that mice fed a WSD have an altered colonic microbiota composition that causes increased penetrability and a reduced growth rate of the inner mucus layer. Both barrier defects can be prevented by transplanting microbiota from chow-fed mice. In addition, we found that administration of Bifidobacterium longum was sufficient to restore mucus growth, whereas administration of the fiber inulin prevented increased mucus penetrability in WSD-fed mice. We hypothesize that the presence of distinct bacteria is crucial for proper mucus function. If confirmed in humans, these findings may help to better understand diseases with an affected mucus layer, such as ulcerative colitis.
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