Journal
CELL HOST & MICROBE
Volume 23, Issue 6, Pages 845-+Publisher
CELL PRESS
DOI: 10.1016/j.chom.2018.05.001
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Funding
- Vanderbilt University Medical Center
- NIH [R01 AI131722]
- Tennessee Center for AIDS Research [P30 AI110527]
- CTSA award from the National Center for Advancing Translational Sciences [KL2TR000446]
- Medical Research Council of South Africa
- NIAID [U19 AI51794, 1U01AI136677, T32AI112541]
- Human Vaccines Project
- NIGMS [T32GM8320]
- Vanderbilt Institute for Clinical and Translational Research (VICTR) (CTSA award) [UL1TR002243]
- NHLBI [T32HL069765]
- Vanderbilt Program for Next Generation Vaccines
- Global Health Vaccine Accelerator Platforms - Bill and Melinda Gates Foundation [48]
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Characterization of single antibody lineages within infected individuals has provided insights into the development of Env-specific antibodies. However, a systems-level understanding of the humoral response against HIV-1 is limited. Here, we interrogated the antibody repertoires of multiple HIV-infected donors from an infection-naive state through acute and chronic infection using next-generation sequencing. This analysis revealed the existence of public'' antibody clonotypes that were shared among multiple HIV-infected individuals. The HIV-1 reactivity for representative antibodies from an identified public clonotype shared by three donors was confirmed. Furthermore, a meta-analysis of publicly available antibody repertoire sequencing datasets revealed antibodies with high sequence identity to known HIV-reactive antibodies, even in repertoires that were reported to be HIV naive. The discovery of public antibody clonotypes in HIV-infected individuals represents an avenue of significant potential for better understanding antibody responses to HIV-1 infection, as well as for clonotype-specific vaccine development.
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