Journal
CELL HOST & MICROBE
Volume 23, Issue 4, Pages 447-+Publisher
CELL PRESS
DOI: 10.1016/j.chom.2018.03.002
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Funding
- NIH, National Cancer Institute [P01-CA023766]
- NIH, National Heart, Lung, and Blood Institute [R01-HL069929, R01 HL124112]
- NIH, National Institute of Allergy and Infectious Diseases [R01-AI100288]
- NIH, National Institute of Diabetes and Digestive and Kidney Diseases [DK048873, DK056626, DK103046]
- Lymphoma Foundation
- Susan and Peter Solomon Divisional Genomics Program
- Memorial Sloan Kettering Cancer Center Support Grant/Core Grant [P30 CA008748]
- Parker Institute for Cancer Immunotherapy at Memorial Sloan Kettering Cancer Center
- Cancer Prevention and Research Institute of Texas [RR160089]
- Seres Therapeutics
- Swedish Research Council [2016-00149]
- Swedish Society for Medical Research [P14-0090]
- Swedish Society of Medicine [SLS-499181]
- NATIONAL CANCER INSTITUTE [P30CA008748, P30CA016672, P01CA023766] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL124112, R01HL069929] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI101406, R01AI080455, R01AI100288, U01AI124275] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R37DK048873, R01DK103046, R01DK056626, R01DK048873, R29DK048873] Funding Source: NIH RePORTER
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Bone marrow transplantation (BMT) offers curative potential for patients with high-risk hematologic malignancies, but the post-transplantation period is characterized by profound immunodeficiency. Recent studies indicate that the intestinal microbiota not only regulates mucosal immunity, but can also contribute to systemic immunity and hematopoiesis. Using antibiotic-mediated microbiota depletion in a syngeneic BMT mouse model, here we describe a role for the intestinal flora in hematopoietic recovery after BMT. Depletion of the intestinal microbiota resulted in impaired recovery of lymphocyte and neutrophil counts, while recovery of the hematopoietic stem and progenitor compartments and the erythroid lineage were largely unaffected. Depletion of the intestinal microbiota also reduced dietary energy uptake and visceral fat stores. Caloric supplementation through sucrose in the drinking water improved post-BMT hematopoietic recovery in mice with a depleted intestinal flora. Taken together, we show that the intestinal microbiota contribute to post-BMT hematopoietic reconstitution in mice through improved dietary energy uptake.
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