Journal
CELL CYCLE
Volume 17, Issue 10, Pages 1155-1172Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15384101.2018.1464847
Keywords
Meiotic recombination; DNA double-strand break; ATM; Tel1 kinase
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Funding
- NIH [P30 CA008748, R35 GM118092, R35 GM118175]
- March of Dimes grant [1-FY17-799]
- NATIONAL CANCER INSTITUTE [P30CA008748] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R35GM118175, R35GM118092] Funding Source: NIH RePORTER
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DNA double-strand breaks (DSBs) generated by the SPO11 protein initiate meiotic recombination, an essential process for successful chromosome segregation during gametogenesis. The activity of SPO11 is controlled by multiple factors and regulatory mechanisms, such that the number of DSBs is limited and DSBs form at distinct positions in the genome and at the right time. Loss of this control can affect genome integrity or cause meiotic arrest by mechanisms that are not fully understood. Here we focus on the DSB-responsive kinase ATM and its functions in regulating meiotic DSB numbers and distribution. We review the recently discovered roles of ATM in this context, discuss their evolutionary conservation, and examine future research perspectives.
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