Journal
CELL BIOLOGY INTERNATIONAL
Volume 42, Issue 4, Pages 384-392Publisher
WILEY
DOI: 10.1002/cbin.10915
Keywords
AMPK; ATP synthesis and consumption; energy metabolism
Categories
Funding
- Nature Science Foundation of Jiangxi province of China [20171BAB205062, 20171BCB23086]
- National Nature Science Foundation of China [81460374, 81572753, 31460304]
- Health and Family Planning Commission of Jiangxi province of China [700779002, 70434003]
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AMP-activated protein kinase (AMPK) is a conserved sensor of cellular energy change and is activated by increased AMP/ATP and/or ADP/ATP ratios. AMPK maintains the energy balance by decreasing the ATP-consuming processes such as transcription of synthetic fat genes and rRNA, the translation of ribosomal proteins, synthesis of cholesterol and fatty acid, while the metabolic pathways such as glucose and fatty transport, fatty acid oxidation, autophagy, mitochondrial synthesis and oxidative metabolism are increased to preserve ATP during energy deficiency. Recent advance has demonstrated that AMPK activity has a close association with the initiation and progression in various cancers. Here we review the mechanisms that AMPK controls energy metabolism through regulating ATP synthesis and consumption, and further discuss the deregulation of AMPK in cancers.
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