Journal
CELL AND TISSUE RESEARCH
Volume 374, Issue 1, Pages 1-15Publisher
SPRINGER
DOI: 10.1007/s00441-018-2871-5
Keywords
Mesenchymal stromal (stem) cells; Extracellular vesicles; Exosomes; Mesenchymal stromal cell-derived extracellular vesicles; Sepsis
Categories
Funding
- National Natural Science Foundation of China [81671956, 81570071, 81772122]
- Zhejiang Provincial Program for the Cultivation of High-level Innovative Health Talents [2016-6]
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Mesenchymal stromal (stem) cells (MSCs) have multipotent differentiation capacity and exist in nearly all forms of post-natal organs and tissues. The immunosuppressive and anti-inflammatory properties of MSCs have made them an ideal candidate in the treatment of diseases, such as sepsis, in which inflammation plays a critical role. One of the key mechanisms of MSCs appears to derive from their paracrine activity. Recent studies have demonstrated that MSC-derived extracellular vesicles (MSC-EVs) are at least partially responsible for the paracrine effect. MSC-EVs transfer molecules (such as proteins/peptides, mRNA, microRNA and lipids) with immunoregulatory properties to recipient cells. MSC-EVs have been shown to mimic MSCs in alleviating sepsis and may serve as an alternative to whole cell therapy. Compared with MSCs, MSC-EVs may offer specific advantages due to lower immunogenicity and higher safety profile. The first two sections of the review discuss the preclinical and clinical findings of MSCs in sepsis. Next, we review the characteristics of EVs and MSC-EVs. Then, we summarize the mechanisms of MSC-EVs, including tissue regeneration and immunomodulation. Finally, our review presents the evidences that MSC-EVs are effective in treating models of sepsis. In conclusion, MSC-EVs may have the potential to become a novel therapeutic strategy for sepsis.
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