Journal
CELL AND TISSUE RESEARCH
Volume 371, Issue 3, Pages 437-453Publisher
SPRINGER
DOI: 10.1007/s00441-017-2774-x
Keywords
Leukocyte trafficking; Ectodomain shedding; Signalling; L-selectin; Neutrophil
Categories
Funding
- British Heart Foundation
- Medical Research Council
- BBSRC
- Biotechnology and Biological Sciences Research Council [BB/J007692/1, 1382555, 1209935] Funding Source: researchfish
- Medical Research Council [1521071] Funding Source: researchfish
- BBSRC [BB/J007692/1] Funding Source: UKRI
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L-selectin is a type I transmembrane cell adhesion molecule expressed on most circulating leukocytes, including neutrophils. Engagement of L-selectin with endothelial-derived ligands initiates neutrophil tethering and rolling behaviour along luminal walls of post-capillary venules, constituting the first step of the multi-step adhesion cascade. There is a large body of evidence to suggest that signalling downstream of L-selectin can influence neutrophil behaviour: adhesion, migration and priming. This review will cover aspects of L-selectin form and function and introduce the triad of L-selectin regulation, highlighting the inextricable links between adhesion, signalling and ectodomain shedding and also highlighting the cytosolic proteins that interconnect them. Recent advances in how L-selectin impacts priming, transendothelial migration (TEM) and cell polarity will also be discussed.
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