Journal
CELL
Volume 173, Issue 6, Pages 1329-+Publisher
CELL PRESS
DOI: 10.1016/j.cell.2018.04.004
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Funding
- JPB Foundation
- PIIF
- PNDRF
- JFDP
- Whitehall Foundation
- Klingenstein Foundation
- NARSAD Young Investigator Award
- Alfred P. Sloan Foundation
- New York Stem Cell Foundation
- McKnight Foundation
- Whitehead Career Development Chair
- NIMH [R01-MH102441-01]
- NIA [RF1-AG047661-01]
- NIH Director's New Innovator Award [DP2-DK-102256-01]
- NIH Director's Pioneer Award [DP1-AT009925]
- Jeffrey and Nancy Halis Fellowship
- Henry E. Singleton Fund
- NLM training grant
- Simons Center
- Netherlands Organization for Scientific Research (NWO) RUBICON fellowship program
- NARSAD Young Investigator Grant from the Brain & Behavior Research Foundation
- NSF Graduate Research Fellowships (NSF GRFP), an Integrative Neuronal Systems Training Fellowship [T32 GM007484]
- Training Program in the Neurobiology of Learning and Memory
- NIH [1-R01-AG-050548-01, DP1-OD003646, R01-GM104948]
- Singleton fellowship
- Leventhal fellowship
- Whitaker fellowship
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Observational learning is a powerful survival tool allowing individuals to learn about threat-predictive stimuli without directly experiencing the pairing of the predictive cue and punishment. This ability has been linked to the anterior cingulate cortex (ACC) and the basolateral amygdala (BLA). To investigate how information is encoded and transmitted through this circuit, we performed electrophysiological recordings in mice observing a demonstrator mouse undergo associative fear conditioning and found that BLA-projecting ACC (ACC -> BLA) neurons preferentially encode socially derived aversive cue information. Inhibition of ACC -> BLA alters real-time amygdala representation of the aversive cue during observational conditioning. Selective inhibition of the ACC -> BLA projection impaired acquisition, but not expression, of observational fear conditioning. We show that information derived from observation about the aversive value of the cue is transmitted from the ACC to the BLA and that this routing of information is critically instructive for observational fear conditioning.
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