Journal
CELL
Volume 172, Issue 6, Pages 1260-1270Publisher
CELL PRESS
DOI: 10.1016/j.cell.2017.10.045
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Funding
- Israel Science Foundation [1360/16, 1796/12]
- European Research Council (ERC) [ERC-CoG 681203]
- DFG SPP program [SO 1611/1-1]
- Abisch-Frenkel Foundation
- David and Fela Shapell Family Foundation INCPM Fund
- Benoziyo Advancement of Science grant
- Minerva Foundation
- Pasteur-Weizmann council
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Bacteriophages, discovered about a century ago, have been pivotal as models for understanding the fundamental principles of molecular biology. While interest in phage biology declined after the phage golden era,'' key recent developments, including advances in phage genomics, microscopy, and the discovery of the CRISPR-Cas anti-phage defense system, have sparked a renaissance in phage research in the past decade. This review highlights recently discovered unexpected complexities in phage biology, describes a new arsenal of phage genes that help them overcome bacterial defenses, and discusses advances toward documentation of the phage biodiversity on a global scale.
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