Journal
CELL
Volume 172, Issue 1-2, Pages 14-21Publisher
CELL PRESS
DOI: 10.1016/j.cell.2017.11.011
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Funding
- Chan Zuckerberg Initiative
- Howard Hughes Medical Institute International Scholar Award
- European Research Council [724471-HemTree2.0]
- Melanoma Research Alliance Established Investigator Award [509044]
- Israel Science Foundation [703/15]
- Ernest and Bonnie Beutler Research Program of Excellence in Genomic Medicine
- Helen and Martin Kimmel Award for Innovative Investigation
- Minerva Stiftung research grant
- Israeli Ministry of Science, Technology, and Space
- David and Fela Shapell Family Foundation
- NeuroMac DFG (German Research Foundation)/Transregional Collaborative Research Center Grant
- Abramson Family Center for Young Scientists
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The immunology field has invested great efforts and ingenuity to characterize the various immune cell types and elucidate their functions. However, accumulating evidence indicates that current technologies and classification schemes are limited in their ability to account for the functional heterogeneity of immune processes. Single-cell genomics hold the potential to revolutionize the way we characterize complex immune cell assemblies and study their spatial organization, dynamics, clonal distribution, pathways, function, and crosstalks. In this Perspective, we consider recent and forthcoming technological and analytical advances in single-cell genomics and the potential impact of those advances on the future of immunology research and immunotherapy.
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