Journal
CELL
Volume 172, Issue 6, Pages 1228-1238Publisher
CELL PRESS
DOI: 10.1016/j.cell.2018.01.037
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Funding
- National Science Foundation Graduate Research Fellowship [1122374]
- Defense Threat Reduction Agency [HDTRA1-15-1-0051]
- NIH [U19AI111276]
- Department of Medicine at the University Hospital of Basel
- Broad Institute Tuberculosis donor group
- Pershing Square Foundation
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Antibiotic tolerance, the capacity of genetically susceptible bacteria to survive the lethal effects of antibiotic treatment, plays a critical and underappreciated role in the disease burden of bacterial infections. Here, we take a pathogen-by-pathogen approach to illustrate the clinical significance of antibiotic tolerance and discuss how the physiology of specific pathogens in their infection environments impacts the mechanistic underpinnings of tolerance. We describe how these insights are leading to the development of species-specific therapeutic strategies for targeting antibiotic tolerance and highlight experimental platforms that are enabling us to better understand the complexities of drug-tolerant pathogens in in vivo settings.
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