Journal
CARCINOGENESIS
Volume 39, Issue 11, Pages 1411-1418Publisher
OXFORD UNIV PRESS
DOI: 10.1093/carcin/bgy095
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Funding
- Ministry of Health of the Czech Republic [15-33999A, 15-28628A]
- National Program of Sustainability I and II (MEYS CR) [LO1304, LQ1605]
- European Union-project ICRC-ERA-HumanBridge [316345]
- Czech Science Foundation [17-08985Y]
- project HistoPARK [CZ.1.07/2.3.00/20.0185]
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The cell surface glycoprotein Trop-2 is commonly overexpressed in carcinomas and represents an exceptional antigen for targeted therapy. Here, we provide evidence that surface Trop-2 expression is functionally connected with an epithelial phenotype in breast and prostate cell lines and in patient tumor samples. We further show that Trop-2 expression is suppressed epigenetically or through the action of epithelial-to-mesenchymal transition transcription factors and that deregulation of Trop-2 expression is linked with cancer progression and poor patient prognosis. Moreover, our data suggest that the cancer plasticity-driven intratumoral heterogeneity in Trop-2 expression may significantly contribute to response and resistance to therapies targeting Trop-2-expressing cells.
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