Journal
CARBOHYDRATE RESEARCH
Volume 465, Issue -, Pages 52-57Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2018.06.008
Keywords
Neoglycoconjugates; Cholesterol-DTPA; Liver targeting; Liposome; Sugar-binding receptor
Funding
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [402603/2016-8]
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Carbohydrate receptors on liver represent attractive targets for receptor-mediated delivery of nanostructured therapeutics. In this study, two new cholesterol-based glycoconjugates derived from D-galactose and N-acetylglucosamine were synthesized and incorporated into liposomes. Tc-99m-Cholesterol-DTPA complex was used for radiolabeling experiments in vivo with high radiochemical yields and stability. Biodistribution studies confirmed the targeting of galactosylated liposomes (GalL) to liver cells. These results indicated that GalL could be considered a promising drug delivery system for liver diseases therapy.
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