Journal
CARBOHYDRATE POLYMERS
Volume 198, Issue -, Pages 124-130Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2018.06.061
Keywords
Glycol chitosan; PEG diglycidyl ether; Hydrogel; Crosslinking; Angiogenesis; Antibacterial
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We aimed at producing a hydrogel from a chitosan (CS) derivative soluble in physiological conditions to avoid any purification step thus allowing to use the materials also as an in-situ forming material. So, we crosslinked glycol chitosan (GCS) with poly(ethylene glycol) diglycidyl ether (PEGDE) in water at 37 degrees C. The scaffolds, referred as GCS-PEG, were specifically designed to be used as wound dressing materials as such (after cross-linking) or as in-situ forming materials. Different amounts of PEGDE were tested. The obtained scaffolds showed macroscopic pores and a tailorable swelling in water by controlling the crosslinking degree. Moreover, GCS-PEG scaffolds displayed a significant antimicrobial activity against Staphylococcus aureus. In-vivo study using the chick embryo choriallantoic membrane resulted in a highly pronounced pro-angiogenic activity suggesting important tissue regeneration properties. Moreover, the employed materials are commercially available, no organic solvents are required and the scaling up is quite predictable.
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