Journal
CARBOHYDRATE POLYMERS
Volume 189, Issue -, Pages 22-30Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2018.01.097
Keywords
Cellulose nanofibrils; 3D printing; Conductive ink; Neural tissue engineering
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Funding
- Knut and Alice Wallenberg Foundation
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Neural tissue engineering (TE), an innovative biomedical method of brain study, is very dependent on scaffolds that support cell development into a functional tissue. Recently, 3D patterned scaffolds for neural TE have shown significant positive effects on cells by a more realistic mimicking of actual neural tissue. In this work, we present a conductive nanocellulose- based ink for 3D printing of neural TE scaffolds. It is demonstrated that by using cellulose nanofibrils and carbon nanotubes as ink constituents, it is possible to print guidelines with a diameter below 1 mm and electrical conductivity of 3.8 x 10(-1) S cm(-1). The cell culture studies reveal that neural cells prefer to attach, proliferate, and differentiate on the 3D printed conductive guidelines. To our knowledge, this is the first research effort devoted to using cost-effective cellulosic 3D printed structures in neural TE, and we suppose that much more will arise in the near future.
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