Journal
CARBOHYDRATE POLYMERS
Volume 197, Issue -, Pages 47-56Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2018.05.062
Keywords
Polyelectrolyte complexes; Hydrogels; Scaffolds; Human adipose-derived stem cells
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Funding
- CAPES agency
- National Council for Scientific and Technological Development - CNPq [0008678964988973, 6143236324614401]
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Processing stable polysaccharide membranes with suitable mechanical properties has been challenging for applications in wound healing and tissue engineering. Here we expand the characterization of pectin/chitosan (PT/CS) membranes (without covalent crosslinking), which we recently reported. Membranes containing pectin (PT) excess were formed, and PT/CS ratio can be tuned to enhance the mechanical strength, and to modulate hydrophilicity and cytocompatibility. The surface wettability and swelling properties of the polyelectrolyte complexes (PECs) played an important role to promote the attachment of stem cells. These PECs membranes have ultimate tensile strength similar to that of human skin, which is on the order of ten times higher than similar previously reported polysaccharide materials. We show for the first time that these new PT/CS membranes may promote anchorage, adhesion and support human stem cell growth, making them candidate materials for tissue engineering purposes.
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