Journal
CARBOHYDRATE POLYMERS
Volume 197, Issue -, Pages 292-304Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2018.05.078
Keywords
Divalent ions; Sodium alginate; Mechanical properties; Antibacterial properties; Wound healing
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Funding
- National Natural Science Foundation of China [51772233, 51572206, 51172171]
- National Key Research and Development Program of China [2016YFC1101605, 2017YFC1103800]
- Science and Technology Support Program of Hubei province [2015BAA085]
- Natural Science Foundation of Hubei Province [2015CFB551]
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Hydrogels are widely used as debriding agents on account of providing a moist environment for wound healing, however the lack of mechanical strength, angiogenesis and antibacterial property limits their applications. In this study, we synthesized novel divalent ion cross-liking hydrogels (copper, zinc, strontium and calcium) and compared the mechanical performance, swelling ratio, antibacterial properties and biocompatibility in vitro and vivo. Thereinto, among the four divalent ions cross-linked hydrogels, copper ion crosslinking exhibited the maximum breaking strength, while strontium and zinc ion cross-linked hydrogels exhibited an excellent mechanical strength. In addition, the swelling ratio and pore size of no-ion cross-linked hydrogels was larger than ion cross-kinked hydrogels. In vitro, the improvements on wound healing after hydrogel application were evaluated by histological and molecular assays by detecting VEGF and TGF-beta expression. In vitro and in vivo study results showed that zinc cross-kinked hydrogel had a spectrum of antibacterial activities, cell viability, mechanical strength and the ability of wound closure by promoting fibroblasts migration, vascularization, collagen deposition and the formation of granulation tissue.
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