Journal
CARBOHYDRATE POLYMERS
Volume 199, Issue -, Pages 193-204Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2018.07.004
Keywords
3-Aminopropyltrimethoxysilane; Tosylcellulose; TiO2 nanoparticles; Hybrid material; BJ1 fibroblast; Antimicrobial activity
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Funding
- Academy of Scientific Research and Technology, Egypt through Egypt-France Scientific and Technological Cooperation Program AMHOTEP
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In the present study, tosylcellulose (TC) was used as a key intermediate for the selective coupling with 3-aminopropyltrimethoxysilane (APTMS) affording amino-propylsilane-grafted tosylcellulose (TC-Si). Solid state C-13 NMR and FT-IR analyses confirmed the coupling and self-condensation of APTMS along TC. The changes in the surface morphology of the functionalized cellulose were identified by SEM imaging. The thermal stability of TC-Si was significantly improved as compared to MCC and TC. A new organic/inorganic hybrid cellulosic material was fabricated by embedding TiO2 nanoparticles into TC-Si network. The new cellulose polymers were investigated for their ability to promote the proliferation of human skin fibroblast (BJ1). The cell cytotoxicity assay showed that both TC and TC-Si possessed moderate toxicity to BJ1 cells by 17% and 23.8%, respectively at 20 mu M. Meanwhile, TC-Si/TiO2 hybrid enhanced the proliferation of BJ1 by 42%. Additionally TC-Si/TiO2 hybrid demonstrated promising antimicrobial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans.
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