Journal
CARBOHYDRATE POLYMERS
Volume 198, Issue -, Pages 462-472Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2018.06.115
Keywords
Manuka honey; Gellan gum; Hydrogel characterization; Mechanical properties; Antibacterial; Cartilage regeneration
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Funding
- Universita degli Studi di Bari
- UK EPSRC Centre for Innovative Manufacturing of Medical Devices (MeDe Innovation, EPSRC) [EP/K029592/1]
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Biomaterials for cartilage repair are still far from clinical requirements, even if several studies recently focused on this topic. In this respect, Nature-derived hydrogels are a promising class of scaffolds for cartilage tissue engineering, mimicking the native cellular microenvironment. However, they frequently lack mechanical features required for cartilage applications and are commonly subjected to infection threat. This work describes the innovative use of Manuka honey as molecular spacer for preparing gellan gum-based composites with intrinsic antibacterial properties and superior compressive Young's modulus in respect of several Nature-derived gels based on chitosan, hyaluronic acid or alginate. The addition of Manuka honey made hydrogels able to inhibit the proliferation of S. aureus and S. epidermidis clinical isolates. Furthermore, no cytotoxic effects were detected on human mesenchymal stem cells seeded on the hydrogels. Moreover, chondrogenesis experiments showed a consistent expression of collagen II and high synthesis of GAGs and proteoglycans, thus indicating the formation of cartilage matrix. Overall, these data suggest that the developed smart composites have a great potential as tools for cartilage tissue engineering.
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