Journal
CARBOHYDRATE POLYMERS
Volume 196, Issue -, Pages 445-456Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2018.05.046
Keywords
Se-enriched Grifola frondosa; Selenium polysaccharide; Cyclophosphamide; Immunomodulatory activity; Antioxidant activity; MAPKs
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Funding
- National Natural Science Foundation of China [31471580]
- Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University [HNSD201702]
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To assess the immunomodulatory and antioxidant activities of a Se-polysaccharide from Se-enriched G. frondosa (Se-GFP-22), immunosuppressed mice models were generated by cyclophosphamide (CTX) administration and then treated with Se-GFP-22. Results showed that Se-GFP-22 could increase thymus and spleen indices, phagocytic index, co-mitogenic (ConA-or LPS-stimulated) activities on splenocytes, DTH reaction, serum hemolysin formation and immunoglobulin (Ig G, Ig A and Ig M) levels in CTX-treated mice. Se-GFP-22 significantly enhanced the antioxidant activity in CTX-treated mice, as shown by the evaluation of GSH-Px, SOD and CAT activities, as well as MDA levels in serum, liver and kidney. Se-GFP-22 strongly stimulated inflammatory cytokines (IL-2 and IFN-gamma) and NO productions by up-regulating mRNA expressions of IL-2, IFN-gamma and iNOS. Se-GFP- 22 possessed the immunomodulatory activity by up-regulating various transcription factors (JNK, ERK, and p38) in MAPKs signaling pathways. This study suggested that Se-GFP-22 may provide an alternative strategy in lessening chemotherapy-induced immunosuppression.
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