Journal
CARBOHYDRATE POLYMERS
Volume 186, Issue -, Pages 54-63Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2018.01.025
Keywords
Injectable hydrogel; Self-healing; Drug delivery; Xanthan gum; Anti-enzymatic hydrolysis
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Funding
- National Natural Science Foundation of China [81571881]
- Key Project of Jiangsu Social Development [BE2016752]
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Injectable hydrogels have been an attractive topic in biomaterials. However, during gelation in vivo, they are easy to disperse due to tissue exudates, thus leading to failure of controlled drug release. To solve this problem, we present a novel polysaccharide-based injectable hydrogel via self-crosslinking of aldehyde-modified xanthan (Xan-CHO) and carboxymethyl-modified chitosan (NOCC). The physical properties were optimized by adjusting the mass ratio of Xan-CHO and NOCC. Experiments revealed that this material exhibited the characteristics of self-healing, anti-enzymatic hydrolysis, biocompatibility and biodegradability. The releasing curve demonstrated stable release of BSA-FITC within 10 h after injection in liquids. After incorporation with a vascular endothelial growth factor, there was an interaction between this biomaterial and the host, which accelerated the reconstruction of the abdominal wall in rats. Therefore, this injectable hydrogel, as a drug delivery system, can prevent drug outburst in a variety of settings and function as a tissue scaffold.
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