Journal
CARBOHYDRATE POLYMERS
Volume 186, Issue -, Pages 110-121Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2018.01.045
Keywords
Electrospinning; Quaternized chitosan; Biomaterial; Nonwoven; Nanofibers; Wound dressing
Categories
Funding
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (Brazil) [CAPES 443/2012]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (Brazil) [CNPq 142002/2014-3, CNPq 311250/2016-5]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (Brazil) [FAPESP 2010/02526-1]
Ask authors/readers for more resources
Blend solutions of poly(epsilon-caprolactone) (PCL) and N-(2-hydroxy)-propyl-3-trimethylammonium chitosan chloride (QCh) were successfully electrospun. The weight ratio PCL/QCh ranged in the interval 95/5-70/30 while two QCh samples were used, namely QCh1 ((DQ) over bar = 47.3%; (DPv) over bar = 2218) and QCh2 ((DQ) over bar = 71.1%; (DPv) over bar = 1427). According to the characteristics of QCh derivative and to the QCh content on the resulting PCL/QCh nonwoven, the nanofibers displayed different average diameter (175 nm-415 nm), and the nonwovens exhibited variable porosity (57.0%-81.6%), swelling capacity (175%-425%) and water vapor transmission rate (1600 gm(-2) 24 h-2500 gm(-2) 24 h). The surface hydrophilicity of nonwovens increases with increasing QCh content, favoring fibroblast (HDFn) adhesion and spreading. Tensile tests revealed that the nonwovens present a good balance between elasticity and strength under both dry and hydrated state. Results indicate that the PCL/QCh electrospun nonwovens are new nanofibers-based biomaterials potentially useful as wound dressings.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available