Journal
CARBOHYDRATE POLYMERS
Volume 195, Issue -, Pages 63-70Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2018.04.085
Keywords
Nanoellulose; Cellulose nanofibers; Hydrogel; Nanoparticle; Nanocomposite
Categories
Funding
- National Natural Science Foundation of China [21706193]
- Young Elite Scientists Sponsorship Program by Tianjin [TJSQNTJ-2017-19]
- Natural Science Foundation of Tianjin [17JCQNJC05200]
- State Key Laboratory of Pulp and Paper Engineering [201768, 201822]
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Bacterial infection and uncontrolled bleeding are the major challenges facing the wound treatment. In order to solve these problems, we have devised a green nanocomposite hydrogel by introducing the aminated silver nanoparticles (Ag-NH2 NPs) and gelatin (G) to carboxylated cellulose nanofibers (CNF). Interpenetrating polymeric network (IPN) was formed by interaction of multicomponent, leading to the non-covalent (dynamic ionic bridges) crosslinked hydrogel CNF/G/Ag. The produced hydrogel dressing with 0.5 mg/mL Ag-NH2 NPs (CNF/G/Ag-0.5) demonstrated stronger mechanical, self-recovery, antibacterial properties, satisfactory hemostatic performance, and appropriate balance of fluids on the wound bed (2093.9 g/m(2) per day). More importantly, the wound healing model evaluation in vitro and in vivo of CNF/G/Ag-0.5 showed an outstanding biocompatibility (similar to 100% infected cell viability) and wound healing efficacy (similar to 90% healed and 83.3% survival after 14 days). Our study paved a highly promising approach to improve the performance of cellulose-based hydrogel dressing and would also be useful for developing ideal skin wound dressings by other green materials.
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