Journal
CARBOHYDRATE POLYMERS
Volume 194, Issue -, Pages 225-235Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2018.04.049
Keywords
Biomaterials conduits; Highly aligned inwall; Porous structure; Seamless sidewall; Peripheral nerve; Tissue engineering
Categories
Funding
- National Natural Science Foundation of China [31500782, 31771054, 51603106, 81701835, 81671823]
- Innovation talent fund of Nantong University [CXZR201507]
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In this study, a facile process for efficient and scalable fabrication of biomaterials conduits with seamless sidewall and longitudinally aligned structure on luminal inwall by combining use of lyophilization and micromolding method was firstly developed and reported. The micropatterned chitosan conduits possessed better mechanical matching with the normal sciatic nerve. The highly aligned microstructure could accelerate the orientation growth of newborn tissue, whereas the porous sidewall is anticipated to be beneficial for loading biofactors and reducing nutrition leakage or neurite exogenesis. The as prepared chitosan conduits with micropatterned inwall are proven to significantly promote the regeneration of 10 mm-gapped sciatic nerve of rat. Taken together, the study provides an important experiment and application basis for design and development of new generation of artificial implants for peripheral nerve regeneration, which may also substantially extend current knowledge concerning the engineered biomaterials conduits for tissue engineering and regenerative medicine.
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