Journal
FITOTERAPIA
Volume 106, Issue -, Pages 158-166Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2015.09.001
Keywords
Dasymaschalon sootepense; Cyclohexene oxides; Chlorohydrins; Cytotoxicity; Anti-HIV-1 RT; Anti-inflammatory
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Funding
- Center of Excellence for Innovation in Chemistry (PERCH-CIC)
- Office of the Higher Education Commission
- Mahidol University under the National Research Universities
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Six new naturally occurring polyoxygenated cyclohexene derivatives together with eight related known derivatives, two known alkaloids, and two known flavonoid derivatives were isolated from bioassay-guided fractionation of the ethyl acetate extract of the leaves and twigs of Dasymaschalon sootepense. The structure elucidation and determination of absolute configurations were established by various spectroscopic methods, X-ray diffraction techniques as well as comparison with the literature data. Several isolated compounds were evaluated for their cytotoxic, anti-HIV-1 RT and anti-inflammatory activities. (C) 2015 Elsevier B.V. All rights reserved.
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