Journal
FITOTERAPIA
Volume 105, Issue -, Pages 228-233Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2015.07.009
Keywords
Platelet aggregation; Platelet ROS production; Platelet NOx production; Dimethylallyloxy-stilbene; Resveratrol
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Funding
- Fondazione Cassa di Risparmio di Perugia [2014/0083/021]
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Stilbenes, including resveratrol, are polyphenols provided with protective actions on the cardiovascular system. Some natural derivatives of resveratrol, like pterostilbene, have a better bioavailability than the parent compound. The aim of the present study was to prepare different substituted stilbenes (dimethylallyloxy-stilbene, dimethylallyloxy-pterostilbene) and compare them with resveratrol, p-hydroxy-stilbene and pterostilbene for their biologic activities on platelet aggregation, platelet radical oxygen species (ROS) production, and platelet nitric oxide (NO) synthesis. The results show that the increase of stilbene derivative lipophilicity enhances their biologic activities. (C) 2015 Elsevier B.V. All rights reserved.
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