Journal
FITOTERAPIA
Volume 104, Issue -, Pages 41-44Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2015.05.004
Keywords
Illiciaceae; Illicium jiadifengpi; Sesquiterpenes; Anti-HBV activity
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Funding
- National Natural Science Foundation of China (NSFC) [81172961]
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Two new compounds, 2S-hydroxyl-jiadifenolide (1) and jiadifenlactone acid (2), and eight known compounds were isolated from the fruits of Illicium jiadifengpi. Their structures were analysed using several spectroscopic techniques, including 1D-, 2D-NMR and HR-ESI-MS experiments. The anti-hepatitis B virus (HBV) activities of the isolates were evaluated via HBV transfection of the Hep G2.2.15 cell line. The inhibitory rates of the most active compounds, compounds 4 and 5, on the HBeAg and HBsAg expression were 28.85 +/- 3.15% and 17.53 +/- 1.81% and 37.93 +/- 2.74% and 23.47 +/- 9.52% at concentrations of 64.94 mu M and 6135 mu M, respectively. (C) 2015 Elsevier B.V. All rights reserved.
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