Journal
CANCER LETTERS
Volume 431, Issue -, Pages 73-84Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2018.05.015
Keywords
Immune checkpoint proteins (ICPs); miRNAs; Cancer immune escape
Categories
Funding
- National Natural Science Foundation of China [81770107, 81270576, 81702722, 81301997, 81772496]
- National Postdoctoral Program for Innovative Talents [BX201700292]
- Natural Science Foundation of Hunan Province [2018JJ3703]
- Strategic Priority Research Program of Central South University [ZLXD2017004]
- Fundamental Research Funds for the Central Universities of Central South University [2018zzts830]
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Immune checkpoint proteins (ICPs) are regulators of immune system. The ICP dysregulation silences the host immune response to cancer-specific antigens, contributing to the occurrence and progress of various cancers. MiRNAs are regulatory molecules and function in mRNA silencing and post-transcriptional regulation of gene expression. MiRNAs that modulate the immunity via ICPs have received increasing attention. Many studies have shown that the expressions of ICPs are directly or indirectly repressed by miRNAs in multiple types of cancers. MiRNAs are also subject to regulation by ICPs. In this review, recent studies of the relationship between miRNAs and ICPs (including the PD-1, PD-L1, CTLA-4, ICOS, B7-1, B7-2, B7-H2, B7-H3, CD27, CD70, CD40, and CD4OL) in cancer immune escape are comprehensively discussed, which provide critical detailed mechanistic insights into the functions of the miRNA-ICP axes and their effects on immune escape, and will be beneficial for the potential applications of immune checkpoint therapy and miRNA-based guidance for personalized medicine as well as for predicting the prognosis.
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