Journal
CANCER LETTERS
Volume 419, Issue -, Pages 203-209Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2018.01.041
Keywords
Glioma; LncRNA; Diagnostic biomarker; Therapeutic target
Categories
Funding
- National Natural Science Foundation of China [31401257, 81530042, 31721003, 31571529, 31571519, 31471250, 31701110, 31571390, 31771506, 81600675]
- Ministry of Science and Technology [2016YFA0101300]
- Fundamental Research Funds for Central Universities [kx0151520172569, 1500219106, 20002310002]
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Glioma is one of most malignant primary tumors of the brain. However, due to a lack of effective means for diagnosing and treating glioma, the prognosis of glioma patients remains poor. Therefore, understanding the molecular mechanism of glioma progression is essential for effective treatment. Long non coding RNAs (IncRNAs) are novel regulators of gene expression at the transcriptional, post-transcriptional and epigenetic levels. Recent evidence indicates that IncRNAs may play important roles in regulating the progression of glioma. In this article, we review the expression profile of IncRNAs in glioma and discuss the functions and known mechanisms of several representative IncRNAs in detail, as well as the prospects of IncRNAs as diagnostic and prognostic biomarkers and therapeutic targets. (C) 2018 Elsevier B.V. All rights reserved.
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