Journal
CANCER LETTERS
Volume 420, Issue -, Pages 228-235Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2018.02.002
Keywords
exomiR; exosome; microRNA; cancer biomarker
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Funding
- UK Medical Research Council [MR/R002061/1]
- MRC [MR/R002061/1] Funding Source: UKRI
- Cancer Research UK [S_3319, 20526, 26094] Funding Source: researchfish
- Medical Research Council [MR/R002061/1] Funding Source: researchfish
- National Institute for Health Research [ACF-2015-26-008, ACF-2012-26-005, CL-2015-26-003] Funding Source: researchfish
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Exosomes are secreted vesicles which can transmit molecular cargo between cells. Exosomal microRNAs (exomiRs) have drawn much attention in recent years because there is increasing evidence to suggest that loading of microRNAs into exosomes is not a random process. Preclinical studies have identified functional roles for exomiRs in influencing many hallmarks of cancer. Mechanisms underpinning their actions, such as exomiR receptors (miRceptors), are now becoming apparent. Even more exciting is the fact that exomiRs are highly suitable candidates for use as non-invasive biomarkers in an era of personalized cancer medicine. (C) 2018 The Authors. Published by Elsevier B.V.
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