Journal
CANCER LETTERS
Volume 421, Issue -, Pages 73-81Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2018.02.024
Keywords
Hepatocellular carcinoma; Insufficient radiofrequency ablation; Autophagy; Hydroxychloroquine
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Funding
- National Science Foundation of China [81671704, 21771042]
- Guangzhou Science and Technology Project [201607010087]
- Natural Science Foundation of Guangdong Province [2016A030310298]
- Guangdong Province Public Research and Capacity-Building of Special Foundation [2015A020211037]
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Radiofrequency ablation (RFA) is considered to be a potentially curative therapy for hepatocellular carcinoma (HCC). However, insufficient RFA (IRFA) can promote rapid progression of the residual tumor. The mechanisms underlying IRFA-induced tumor promotion remain poorly understood. In the present study, we have established a subcutaneous xenograft mouse model and monitored the location and extent of IRFA by dual monitoring with ultrasonography and a thermal imager. For the first time, we provide evidence of the activation of autophagic pathways in mice exposed to IRFA. We show that autophagy plays an important role in relapse and proliferation after IRFA and that hydroxychloroquine (HCQ) can suppress these effects. Our findings indicate that autophagy is involved in experimental IRFA and that inhibition of autophagy may be a novel approach in the treatment of local recurrences of HCC after IRFA in the clinic. (C) 2018 Elsevier B.V. All rights reserved.
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