Journal
CANCER LETTERS
Volume 417, Issue -, Pages 58-64Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2017.12.015
Keywords
LncRNA; Skeletal muscle; Myogenesis
Categories
Funding
- General Research Funds (GRF) from the Research Grants Council (RGC) of the Hong Kong Special Administrative Region [14113514, 14102315, 14133016, 14100415, 14116014]
- Collaborative Research Fund (CRF) from the Ministry of Science and Technology of China [C-6015-14G, 2014CB964700]
- 973 grant from the Ministry of Science and Technology of China [2014CB964700]
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Skeletal muscle myogenesis during development and the injury induced regeneration contribute to the formation and maintenance of muscle tissue. Emerging studies have demonstrated that long non-coding RNAs (IncRNAs) participate in the regulation of gene expression during skeletal myogenesis and their aberrant expression is associated with several muscular diseases. In this review, we summarize recent studies of IncRNAs in the regulation of myogenesis and muscle diseases with mechanistic characterization. These findings have greatly enhanced our understanding of gene regulatory mechanisms governing muscle formation and regeneration, which will eventually lead to novel therapeutics against various muscle diseases. (C) 2017 Elsevier B.V. All rights reserved.
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